Preheat the oven to 350°F (175°C). Ensure it’s fully heated before baking.
In a large bowl, combine ground sausage, shredded cheddar, Bisquick, garlic powder, onion powder, salt, and smoked paprika if using. Mix gently by hand without overworking.
Roll mixture into bite-sized balls (about 1 tablespoon each), roughly 1 inch in diameter, making 30 to 35 balls.
Place sausage balls on a baking sheet lined with parchment paper or a silicone baking mat, spacing about 1 inch apart.
Bake for 20 to 25 minutes until golden and the internal temperature reaches 160°F. Optionally broil for 2 minutes for crispier edges.